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GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Psoriasis is a partially heritable skin disorder, the genetic basis of which is not fully understood. Here, the authors use genome-wide association meta-analysis to discover psoriasis susceptibility loci and genes, which encode existing and potential new drug targets.

Nick Dand
Philip E. Stuart
James T. Elder
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Genome-wide association meta-analysis of AAA identifies 121 independent risk loci and highlights potential therapeutic targets such as proprotein convertase, subtilisin/kexin-type 9 (PCSK9).

Tanmoy Roychowdhury
Derek Klarin
Scott M. Damrauer
ResearchOpen Access16 Oct 2023
Nature Genetics

Volume: 55, P: 1831-1842
Shared genetic risk factors and causal association between psoriasis and coronary artery disease

Coronary artery disease (CAD) and psoriasis are established comorbidities, however their molecular relationship remains unclear. Here, the authors performed trans-disease meta-analysis, highlighting four genetic loci with evidence of colocalization, and prioritized genes based on multiomic data integration.

Matthew T. Patrick
Qinmengge Li
Lam C. Tsoi
ResearchOpen Access02 Nov 2022
Nature Communications

Volume: 13, P: 1-12
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

Systemic sclerosis (SSc) is an autoimmune disease causing skin fibrosis and organ inflammation. Here the authors generate and analyze SSc skin single cell RNA sequencing data to propose contributions from both myofibroblasts and endothelial-to-mesenchymal -transitioning cells (EndoMT) to skin fibrosis, and to implicate the involvement of Hippo signaling pathways.

Feiyang Ma
Pei-Suen Tsou
Johann E. Gudjonsson
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis

Changes in Psoriasis and other inflammatory skin diseases during severity stages can be investigated using single cell and spatial transcriptomics. Here the authors compare different inflammatory skin diseases to emphasise differences in immune cells and inflammatory markers particularly keratinocytes and fibroblasts.

Feiyang Ma
Olesya Plazyo
Johann E. Gudjonsson
ResearchOpen Access12 Jun 2023
Nature Communications

Volume: 14, P: 1-19

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GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis

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