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Showing 1–6 of 6 results
Advanced filters: Author: Rachel E Niec Clear advanced filters

  • In this Viewpoint article, several experts share their thoughts on the plasticity and stability of regulatory T cells, discussing the recent advances in our understanding of the transcriptional and epigenetic regulation of this important T cell subset, as well as the therapeutic implications of this research.

    • Shimon Sakaguchi
    • Dario A. A. Vignali
    • Herman Waldmann
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 461-467

  • Pierre Guermonprez and colleagues have worked out how a subset of dendritic cells expands in individuals with severe malaria. Plasmodium infection causes an accumulation of xanthine in infected red blood cells. The researchers found that type I interferon triggers an increase in the enzyme that metabolizes xanthine to uric acid. Uric acid then acts on mast cells to release Flt3 ligand, an important regulator of dendritic cells, which in turn stimulate T cells to respond to the infection.

    • Pierre Guermonprez
    • Julie Helft
    • Michel C Nussenzweig
    Research
    Nature Medicine
    Volume: 19, P: 730-738

  • Selective impairment of peripheral regulatory T-cell differentiation is found to result in spontaneous allergic TH2-type inflammation in the intestine and lungs, demonstrating the functional heterogeneity of regulatory T cells generated in the thymus and extrathymically in controlling immune mediated inflammation and disease.

    • Steven Z. Josefowicz
    • Rachel E. Niec
    • Alexander Y. Rudensky
    Research
    Nature
    Volume: 482, P: 395-399

  • The transcription factor Foxp3 is essential for the function of regulatory T cells. Rudensky and colleagues show Foxp3 participates in large protein complexes that regulate gene expression of many of these components in self-reinforcing networks.

    • Dipayan Rudra
    • Paul deRoos
    • Alexander Y Rudensky
    Research
    Nature Immunology
    Volume: 13, P: 1010-1019