The authors use a mouse model of rapid-onset dystonia-Parkinsonism to show that an adverse interaction between the cerebellum and basal ganglia can account for the symptoms in this condition. Aberrant cerebellar activity alters basal ganglia function via a di-synaptic thalamic pathway, causing dystonia.
- D Paola Calderon
- Rachel Fremont
- Kamran Khodakhah
