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Showing 1–2 of 2 results
Advanced filters: Author: Rachid Zagani Clear advanced filters

  • The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.

    • Yun Zhao
    • Rachid Zagani
    • Hans-Christian Reinecker
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Sung-Moo Park et al. identify the transcription factor IRF1 as a critical component of the STING signaling complex following microbial c-di nucleotides stimulation and Salmonella infection. They find that activation of IRF1 by STING is required for antigen-specific T cell specification and subsequent host defense response.

    • Sung-Moo Park
    • Tatsushi Omatsu
    • Hans-Christian Reinecker
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-15