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Showing 1–3 of 3 results
Advanced filters: Author: Rachita Dash Clear advanced filters

  • In this work, the authors present their Chloroalkane Azide Membrane Permeability (CHAMP) assay that measures cytosolic accumulation of small molecules in Escherichia coli, enabling rapid profiling of compounds, with the goal to simplify and accelerate antimicrobial drug discovery.

    • George M. Ongwae
    • Zichen Liu
    • Marcos M. Pires
    ResearchOpen Access
    Nature Communications
    P: 1-18

  • Cellular penetration is a crucial property of bioactive molecules to reach intracellular targets, however, current penetration assays are limited when it comes to measuring the exact cytosolic accumulation. Here, the authors introduce a chloroalkane HaloTag azide-based membrane penetration (CHAMP) assay, a high-throughput method using azide tags and click chemistry to accurately measure cytosolic accumulation, offering a powerful tool for the development of drugs targeting intracellular pathways.

    • Sobika Bhandari
    • George M. Ongwae
    • Marcos M. Pires
    ResearchOpen Access
    Communications Chemistry
    Volume: 9, P: 1-14

  • Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

    • Damaris Kinyoki
    • Aaron E. Osgood-Zimmerman
    • Simon I. Hay
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 1761-1782