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Showing 1–4 of 4 results
Advanced filters: Author: Radhakrishnan Padmanabhan Clear advanced filters

  • A series of genetic studies have led to the discovery of novel independent loci and candidate genes associated with red blood cell phenotype; for a proportion of these genes potential single-nucleotide genetic variants are also identified, providing new insights into genetic pathways controlling red blood cell formation, function and pathology.

    • Pim van der Harst
    • Weihua Zhang
    • John C. Chambers
    Research
    Nature
    Volume: 492, P: 369-375

  • Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5’ end of the RNA genome as a promoter for RNA synthesis by the viral polymerase NS5. Here the authors describe the structures of dengue and Zika virus SLAs, identify the SLA-binding site on NS5, and propose models for how NS5 recognizes the RNA promoter.

    • Eunhye Lee
    • Paul J. Bujalowski
    • Kyung H. Choi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Neufeldt et al. evaluate transcriptional and cytokine secretion profiles of cells and patient sera following SARS-CoV-2 infection and detect distinct upregulation of inflammatory cytokines. They also demonstrate that this upregulation is mediated by cGAS-STING and NF-κB signalling, which could provide a potential avenue for the development of future therapies against SARS-CoV-2.

    • Christopher J. Neufeldt
    • Berati Cerikan
    • Ralf Bartenschlager
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15