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Showing 1–4 of 4 results
Advanced filters: Author: Radhika Iyer Clear advanced filters

  • The presence of antibodies to citrullinated protein antigens (ACPA) in peripheral blood represents a risk a state that is ‘at-risk’ for subsequent development of rheumatoid arthritis (RA). Here authors compare multiple molecular and immunological parameters in individuals who are ACPA positive without inflammatory arthritis, ACPA negative controls and patients diagnosed with ACPA positive early-stage RA to conclude that complex immunopathological processes are present in an ACPA positive state which may be targeted by future preventive approaches for RA.

    • Eddie A. James
    • V. Michael Holers
    • Kevin D. Deane
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.

    • Jae-Seung Moon
    • Shady Younis
    • William H. Robinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The ion channel NALCN regulates cell shedding in mice and enhances metastasis in mouse models of cancer. Disseminated cells without oncogenic mutations form normal structures at secondary sites, suggesting that cell shedding is a physiological process that is hijacked during tumorigenesis.

    • Eric P. Rahrmann
    • David Shorthouse
    • Richard J. Gilbertson
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1827-1838