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Showing 1–2 of 2 results
Advanced filters: Author: Raed Ibraheim Clear advanced filters

  • Long-term expression of Cas9 following precision genome editing in vivo may lead to undesirable consequences. Here we show that a single-vector, self-inactivating AAV system containing Cas9 nuclease, guide, and DNA donor can use homology-directed repair to correct disease mutations in vivo.

    • Raed Ibraheim
    • Phillip W. L. Tai
    • Erik J. Sontheimer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.

    • Emmanouela Tsagkaraki
    • Sarah M. Nicoloro
    • Michael P. Czech
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17