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The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Swapping the Xist/Tsix transcriptional units and placing their promoters in each other’s topologically associating domain shows that the topological partitioning of the X-inactivation center is critical to ensure proper X inactivation during development.

Joke G. van Bemmel
Rafael Galupa
Edith Heard
Research27 May 2019
Nature Genetics

Volume: 51, P: 1024-1034
Parental-to-embryo switch of chromosome organization in early embryogenesis

Single-cell allelic HiC analysis, combined with allelic gene expression and chromatin states, reveals parent-of-origin-specific dynamics of chromosome organization and gene expression during mouse preimplantation development.

Samuel Collombet
Noémie Ranisavljevic
Edith Heard
Research25 Mar 2020
Nature

Volume: 580, P: 142-146
Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

Single-cell RNA sequencing of preimplantation mouse embryos demonstrates that lack of paternal Xist leads to genome-wide transcriptional misregulation in the early blastocyst and a failure to activate the extraembryonic pathway.

Maud Borensztein
Laurène Syx
Edith Heard
Research30 Jan 2017
Nature Structural & Molecular Biology

Volume: 24, P: 226-233
Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

X-chromosome inactivation is reversed in the mouse inner cell mass (ICM) through a mechanism that is not fully understood. Here, the authors investigate this process and characterize the contributions of the epigenetic landscape and transcription factors in X-linked gene reactivation dynamics.

Maud Borensztein
Ikuhiro Okamoto
Edith Heard
ResearchOpen Access03 Nov 2017
Nature Communications

Volume: 8, P: 1-14

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The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Parental-to-embryo switch of chromosome organization in early embryogenesis

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

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The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist

Parental-to-embryo switch of chromosome organization in early embryogenesis

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

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