RHO-specific guanine nucleotide dissociation inhibitors (RHOGDIs) had long been considered to be passive inhibitors of RHO GTPases, 'locking' them in an inactive state. However, recent findings suggest that they have integral roles in regulating RHO GTPases, controlling aspects such as stability, expression, activity and membrane localization.
- Rafael Garcia-Mata
- Etienne Boulter
- Keith Burridge
