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Imperfect coordination chemistry facilitates metal ion release in the Psa permease

The PsaA binding protein delivers Mn²⁺ to the human pathogen Streptococcus pneumoniae. Structural and biochemical studies now explain its metal specificity, showing that metal binding induces a closed complex that is reversible for the desired substrate but irreversible for the inhibitor Zn²⁺.

Rafael M Couñago
Miranda P Ween
Christopher A McDevitt
Research10 Nov 2013
Nature Chemical Biology

Volume: 10, P: 35-41
Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

The molecular basis for the high toxicity of cadmium is unclear. Here, Begg et al. use the bacterium Streptococcus pneumoniaeas a model system, and show that cadmium uptake increases sensitivity to oxidative stress by reducing intracellular concentrations of manganese and zinc through different mechanisms.

Stephanie L. Begg
Bart A. Eijkelkamp
Christopher A. McDevitt
ResearchOpen Access03 Mar 2015
Nature Communications

Volume: 6, P: 1-11
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity

Anirban Ghoshal
Edwin G. Tse
Timothy M. Willson
ResearchOpen Access01 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
Binding and structural analyses of potent inhibitors of the human Ca²⁺/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

Gerson S. Profeta
Caio V. dos Reis
Rafael M. Couñago
ResearchOpen Access11 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Rafael M. Couñago
Charles K. Allerston
Opher Gileadi
ResearchOpen Access08 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

André da Silva Santiago
Rafael M. Couñago
Jonathan M. Elkins
ResearchOpen Access04 Oct 2018
Scientific Reports

Volume: 8, P: 1-10

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Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity

Binding and structural analyses of potent inhibitors of the human Ca²⁺/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

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Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

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Binding and structural analyses of potent inhibitors of the human Ca²⁺/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors