Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8+ neurons contribute to regulating both innate and adaptive immune responses against HSV-1, thereby offering a potential target for therapy.
- Jessica Filtjens
- Anais Roger
- Sophie Ugolini
