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Advanced filters: Author: Raghd Rostom Clear advanced filters

Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes

Cardelino leverages variant information from single-cell RNA-seq data for inferring clonal tree configuration and mapping cells to their clone of origin.

Davis J. McCarthy
Raghd Rostom
Sarah A. Teichmann
Research16 Mar 2020
Nature Methods

Volume: 17, P: 414-421
Gene expression variability across cells and species shapes innate immunity

Comparison of transcriptomic data from immune-stimulated cells across different species sheds light on the architecture of the innate immune response.

Tzachi Hagai
Xi Chen
Sarah A. Teichmann
Research24 Oct 2018
Nature

Volume: 563, P: 197-202
Mapping interindividual dynamics of innate immune response at single-cell resolution

GASPACHO is a statistical method that identifies nonlinear dynamic genetic effects using single-cell RNA-seq data. Analysis of an antiviral response in human fibroblasts identifies 1,275 expression QTLs, many of which colocalize with risk loci for autoimmune and infectious diseases.

Natsuhiko Kumasaka
Raghd Rostom
Sarah A. Teichmann
ResearchOpen Access12 Jun 2023
Nature Genetics

Volume: 55, P: 1066-1075