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Advanced filters: Author: Raghu Machiraju Clear advanced filters

Canonical and atypical E2Fs regulate the mammalian endocycle

In mammals, polyploidy is only seen in liver hepatocytes and in trophoblast giant cells in the placenta. Leone and colleagues now show that ploidy is controlled in an antagonistic fashion by canonical E2F transcriptional activators and atypical E2F7 and E2F8 repressors, through the control of G2/M-associated genes.

Hui-Zi Chen
Madhu M. Ouseph
Gustavo Leone
Research14 Oct 2012
Nature Cell Biology

Volume: 14, P: 1192-1202
Redeployment of Myc and E2f1–3 drives Rb-deficient cell cycles

Leone and colleagues find that in intestinal crypt cells, Myc and E2F transcription factors control the transition into the G₂ phase of the cell cycle, but in the absence of Rb, Myc and E2f3a drive S phase entry and ectopic proliferation in vivo.

Huayang Liu
Xing Tang
Gustavo Leone
Research20 Jul 2015
Nature Cell Biology

Volume: 17, P: 1036-1048
Spatial cell type composition in normal and Alzheimers human brains is revealed using integrated mouse and human single cell RNA sequencing

Travis S. Johnson
Shunian Xiang
Jie Zhang
ResearchOpen Access22 Oct 2020
Scientific Reports

Volume: 10, P: 1-14