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Showing 1–4 of 4 results
Advanced filters: Author: Ragini Bhargava Clear advanced filters

  • Telomeres are endogenous cellular targets of DNA ADP-ribosylation (DNA-ADPr). TARG1-regulated DNA-ADPr is coupled to lagging telomere DNA strand synthesis, and persistent DNA-ADPr, due to TARG1 deficiency, leads to telomere shortening and fragility.

    • Anne R. Wondisford
    • Junyeop Lee
    • Roderick J. O’Sullivan
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 791-800

  • DNAPKcs and its kinase activity are required for blunt DNA break end joining when the bridging factor XLF is weakened, but for homologous recombination and radiation resistance, the influence of DNAPKcs is not further enhanced with loss of XLF.

    • Metztli Cisneros-Aguirre
    • Felicia Wednesday Lopezcolorado
    • Jeremy M. Stark
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Proteomic definition of the telomeric PARylome combined with genetic and histone H3.3 deposition assays at telomeres reveals that PAR-regulated HIRA activity compensates for loss of ATRX in ALT cells.

    • Song My Hoang
    • Nicole Kaminski
    • Roderick J. O’Sullivan
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 1152-1164

  • Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tools, and define a role of CNHEJ factor XLF in repair.

    • Ragini Bhargava
    • Manbir Sandhu
    • Jeremy M. Stark
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14