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Showing 1–3 of 3 results
Advanced filters: Author: Rainer Merkl Clear advanced filters

    • HANS-JOACHIM FRITZ
    • RAINER MERKL
    • MANFRED KRÖGER
    Research
    Nature
    Volume: 355, P: 595-596

  • Argonaute (Ago) proteins that cleave target RNAs are known as slicer enzymes. Extensive mutagenesis studies combined with in vitro cleavage assays and structural modeling have now enabled catalytically inactive human Ago1 and Ago3 to be turned into slicer enzymes, providing insight into the molecular basis of human Ago1 and Ago3 inactivity.

    • Judith Hauptmann
    • Anne Dueck
    • Gunter Meister
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 814-817