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Showing 1–3 of 3 results

Advanced filters: Author: Rainier Amora Clear advanced filters

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

This study extends the natural code by which transcription activation–like effector nucleases (TALENs) recognize DNA and uses the resulting expanded repertoire of repeat divariable residues (RVDs) to improve TALEN performance.

Jeffrey C Miller
Lei Zhang
Edward J Rebar
Research23 Mar 2015
Nature Methods

Volume: 12, P: 465-471
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Zinc finger protein transcription factors are developed for the selective silencing of the mutant huntingtin gene in human neurons in vitro and multiple animal models of Huntington’s disease in vivo while preserving expression of the wild-type allele.

Bryan Zeitler
Steven Froelich
H Steve Zhang
Research01 Jul 2019
Nature Medicine

Volume: 25, P: 1131-1142
Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Yannick Doyon
Jasmine M McCammon
Sharon L Amacher
Research25 May 2008
Nature Biotechnology

Volume: 26, P: 702-708