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Showing 1–4 of 4 results

Advanced filters: Author: Rajashree A. Deshpande Clear advanced filters

Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

Deshpande et al show that MRN nuclease-dependent processing of DNA ends in human cells occurs at sites bound by DNA-PK. Chromatin immunoprecipitation analysis of DNA-PK, MRN, and CtIP supports a sequential model of pathway choice.

Rajashree A. Deshpande
Alberto Marin-Gonzalez
Tanya T. Paull
ResearchOpen Access16 Sept 2023
Nature Communications

Volume: 14, P: 1-17
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma

Lou and colleagues describe the role of METTL16 in homologous recombination repair and demonstrate that PARP inhibition may be beneficial in the treatment of PDAC that is characterized by high METTL16.

Xiangyu Zeng
Fei Zhao
Zhenkun Lou
Research22 Sept 2022
Nature Cancer

Volume: 3, P: 1088-1104
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.

Jacob Paiano
Wei Wu
André Nussenzweig
ResearchOpen Access12 Feb 2020
Nature Communications

Volume: 11, P: 1-15
EXD2 promotes homologous recombination by facilitating DNA end resection

DNA resection is the first step of double-strand break repair by homologous recombination. Broderick et al. find that EXD2 plays a key role in this process by acting as an essential cofactor for the MRN complex.

Ronan Broderick
Jadwiga Nieminuszczy
Wojciech Niedzwiedz
Research25 Jan 2016
Nature Cell Biology

Volume: 18, P: 271-280