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Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering

Philipp Mueller
Jan Massner
Jean Pieters
Research16 Mar 2008
Nature Immunology

Volume: 9, P: 424-431
Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

The blood circulation time is important to the biomedical application of nanomaterials. Here, the authors explore the effect of protein corona formation on the blood residency of nanomaterials and show circulation times are governed by the dynamic remodelling of protein opsonins in vivo.

Srinivas Abbina
Lily E. Takeuchi
Jayachandran N. Kizhakkedathu
ResearchOpen Access16 Jun 2020
Nature Communications

Volume: 11, P: 1-12
Polyvalent choline phosphate as a universal biomembrane adhesive

The headgroup of phospholipids in eukaryotic cell membranes contains phosphatidyl choline (PC). Now, branched polyglycerols decorated with the 'PC-inverse' choline phosphate (CP) are shown to behave as 'universal' biomembrane adhesives, binding electrostatically to cell membranes and to PC-containing liposomes. Binding can be reversed by exposure to PC-containing polymers. These adhesives may find use as tissue sealants and as drug-delivery vehicles.

Xifei Yu
Zonghua Liu
Donald E. Brooks
Research18 Mar 2012
Nature Materials

Volume: 11, P: 468-476
Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells

The use of alternative polyadenylation sites can potentially result in mRNA being more or less susceptible to interaction with modulators of translation or stability. Here Gruber et al. find that the shortening of 3′UTRs observed in proliferating T cells does not significantly impact protein abundance.

Andreas R. Gruber
Georges Martin
Mihaela Zavolan
Research21 Nov 2014
Nature Communications

Volume: 5, P: 1-10
On guard: coronin proteins in innate and adaptive immunity

Coronins were first characterized on the basis of their interactions with the actin cytoskeleton and were later linked to immune dysfunction. In this short, focused Review, the authors discuss the emerging roles of coronins in immune cell signalling.

Jean Pieters
Philipp Müller
Rajesh Jayachandran
Reviews14 Jun 2013
Nature Reviews Immunology

Volume: 13, P: 510-518
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

Many proteases are important drug targets, but identification of their substrates remains challenging. By using polymers to selectively isolate N-terminal peptides generated by proteolysis of complex samples, Kleifeld et al. identify substrates of clinically relevant proteases with broad specificity.

Oded Kleifeld
Alain Doucet
Christopher M Overall
Research07 Mar 2010
Nature Biotechnology

Volume: 28, P: 281-288
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

Delnaz Roshandel
Eric J. Sanders
Helen Cockerill
ResearchOpen Access28 Sept 2023
npj Genomic Medicine

Volume: 8, P: 1-11

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Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering

Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

Polyvalent choline phosphate as a universal biomembrane adhesive

Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells

On guard: coronin proteins in innate and adaptive immunity

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

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