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Showing 1–5 of 5 results
Advanced filters: Author: Rajkumar Noubade Clear advanced filters

  • Microglia are the tissue-resident macrophages of the brain. Ouyang and colleagues show the ER-resident transmembrane protein NRROS is necessary for proper development and function of microglia. Mice lacking NRROS exhibit neurologic defects and die prematurely.

    • Kit Wong
    • Rajkumar Noubade
    • Wenjun Ouyang
    Research
    Nature Immunology
    Volume: 18, P: 633-641

  • The Crohn’s disease risk-conferring T300A variant in the autophagy protein ATG16L1 increases its sensitivity to caspase-3-mediated cleavage; this decreases the induction of autophagy in response to metabolic stress or pathogen infection, leading to increased secretion of inflammatory cytokines.

    • Aditya Murthy
    • Yun Li
    • Menno van Lookeren Campagne
    Research
    Nature
    Volume: 506, P: 456-462

  • The deubiquitinase enzyme DUBA is shown to act as a negative regulator of interleukin-17A (IL-17A) in TH17 cells; DUBA interacts with and stabilizes the ubiquitin ligase UBR5, which in turn targets RORγt for degradation in the proteaseome, thus limiting IL-17A production.

    • Sascha Rutz
    • Nobuhiko Kayagaki
    • Vishva M. Dixit
    Research
    Nature
    Volume: 518, P: 417-421