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Showing 1–5 of 5 results
Advanced filters: Author: Rajula Elango Clear advanced filters

  • Break-induced replication (BIR) is a double-strand break repair pathway that can lead to genomic instability. Here the authors show that the absence of Srs2 helicase during BIR leads to uncontrolled binding of Rad51 to single-stranded DNA, which promotes the formation of toxic intermediates that need to be resolved by Mus81 or Yen1.

    • Rajula Elango
    • Ziwei Sheng
    • Anna Malkova
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • This paper demonstrates that the mechanism of break-induced replication (BIR) is significantly different from S-phase replication, as it proceeds via a migrating bubble driven by Pif1 helicase, results in conservative inheritance of newly synthesized DNA, and is inherently mutagenic.

    • Natalie Saini
    • Sreejith Ramakrishnan
    • Anna Malkova
    Research
    Nature
    Volume: 502, P: 389-392

  • The choice between the major DNA double-strand break repair pathways is important for maintaining genomic stability. In mammals, selecting one pathway over another involves a complex series of binary ‘decisions’. Emerging evidence suggests that the ‘decision tree’ governing repair-pathway choice at stalled replication forks differs from that of replication-independent double-strand breaks.

    • Ralph Scully
    • Arvind Panday
    • Nicholas A. Willis
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 698-714