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Showing 1–4 of 4 results
Advanced filters: Author: Rakela Lubonja Clear advanced filters

  • Two sequence-verified, clonal, publicly available collections of human open reading frames are reported. One collection is in a lentiviral vector for expression in mammalian cells; the other is in the Gateway vector system.

    • Xiaoping Yang
    • Jesse S Boehm
    • David E Root
    Research
    Nature Methods
    Volume: 8, P: 659-661

  • CERES is a new computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for copy number effects and variable sgRNA activity. Applying CERES to new genome-scale CRISPR–Cas9 essentiality screen data from 342 cancer cell lines and other published data sets shows that CERES decreases false-positive results and provides consistent estimates of sgRNA activity.

    • Robin M Meyers
    • Jordan G Bryan
    • Aviad Tsherniak
    Research
    Nature Genetics
    Volume: 49, P: 1779-1784

  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218

  • The genome of the grey short-tailed opossum Monodelphis domestica has been sequenced and analyzed, giving a first peek at a marsupial's genetic code. Of particular interest are the genetics of the immune system, which has been studied as a model for humans, and of the X chromosome for historical reasons.

    • Tarjei S. Mikkelsen
    • Matthew J. Wakefield
    • Kerstin Lindblad-Toh
    Research
    Nature
    Volume: 447, P: 167-177