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Nature Structural & Molecular Biology (1)

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Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

Methylation of the lysine demethylase KDM1A and the recognition of this modification by the chromodomain helicase CHD1 control androgen-dependent gene transcription and TMPRSS2-ERG gene fusion, a common translocation event in prostate cancer.

Eric Metzger
Dominica Willmann
Roland Schüle
Research11 Jan 2016
Nature Structural & Molecular Biology

Volume: 23, P: 132-139

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Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

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