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Nature Communications (4)

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Showing 1–4 of 4 results

Advanced filters: Author: Ramanuj Banerjee Clear advanced filters

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system

CXCR3 and CXCR7 are chemokine receptors involved in cellular migration in physiological and pathophysiological context. Here, the authors present cryo-EM structures of CXCR3 in complex with small molecule agonists and discover their dual-agonism at CXCR7.

Shirsha Saha
Fumiya K. Sano
Arun K. Shukla
ResearchOpen Access28 Mar 2025
Nature Communications

Volume: 16, P: 1-18
Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

GPR109A is a prototypical GPCR and a key drug target for dyslipidemia. Here, the authors present cryo-EM structures of this receptor to elucidate agonist-binding and activation, and design receptor mutants with transducer-coupling-bias.

Manish K. Yadav
Parishmita Sarma
Arun K. Shukla
ResearchOpen Access02 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

G protein-coupled receptors (GPCRs) are integral membrane proteins and the largest class of drug targets in the human genome. Here, Baidya et al. show that a synthetic antibody can be used to modulate GPCR trafficking and signaling in live cells.

Mithu Baidya
Madhu Chaturvedi
Arun K. Shukla
ResearchOpen Access08 Aug 2022
Nature Communications

Volume: 13, P: 1-18
Functional competence of a partially engaged GPCR–β-arrestin complex

β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for receptor endocytosis and signalling.

Punita Kumari
Ashish Srivastava
Arun K. Shukla
ResearchOpen Access09 Nov 2016
Nature Communications

Volume: 7, P: 1-16