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Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation

During vectorial protein translation, native interactions are temporarily unsatisfied. Here, authors introduce “Native Fold Delay”, integrating protein topology with translation kinetics to quantify the resulting delays in co-translational folding which may result in protein aggregation.

Ramon Duran-Romaña
Bert Houben
Joost Schymkowitz
ResearchOpen Access15 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

Protein biosynthesis is a major target of existing antibiotics that inhibit the efficiency or fidelity of the bacterial ribosome. Here, the authors show that a synthetic peptide displays bactericidal activity through a different mechanism, inducing co-translational aggregation of nascent peptidic chains.

Laleh Khodaparast
Ladan Khodaparast
Frederic Rousseau
ResearchOpen Access12 Feb 2025
Nature Communications

Volume: 16, P: 1-18
PyUUL provides an interface between biological structures and deep learning algorithms

While artificial intelligence (AI) is quickly becoming ubiquitous, biology still suffers from the lack of interfaces connecting biological structures and modern AI methods. Here, the authors report PyUUL, a library to translate biological structures into 3D differentiable tensorial representations.

Gabriele Orlando
Daniele Raimondi
Frederic Rousseau
ResearchOpen Access18 Feb 2022
Nature Communications

Volume: 13, P: 1-9
Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Here the authors show that beta-lactamase have an intrinsic aggregation propensity that can be exploited to inactivate these enzymes that mediate antibiotic resistance, using peptides that are based on aggregation prone regions in the sequence of the beta-lactamase.

Ladan Khodaparast
Laleh Khodaparast
Joost Schymkowitz
ResearchOpen Access09 Sept 2023
Nature Communications

Volume: 14, P: 1-16
MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

Cedric Thues
Jorge S. Valadas
Hilde Van Esch
ResearchOpen Access02 Mar 2021
Scientific Reports

Volume: 11, P: 1-13

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Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation

Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

PyUUL provides an interface between biological structures and deep learning algorithms

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

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