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Showing 1–4 of 4 results
Advanced filters: Author: Ramreddy Tippana Clear advanced filters

  • DHX36 is a G-quadruplex (G4) resolving helicase that targets both DNA-G4 and RNA-G4. Here the authors use single molecule FRET measurements and show that DHX36 resolves RNA-G4 structures by a mechanism involving an ATP-dependent, highly repetitive and stepwise refolding of RNA-G4 that differs from its DNA-G4 structures resolving mechanism.

    • Ramreddy Tippana
    • Michael C. Chen
    • Sua Myong
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • How G-quadruplexes (G4s) are resolved by helicases is still a matter of investigation. Here the authors provide mechanistic insight into G4s unwinding by presenting a crystal structure of resolved G4 DNA and the G4 binding domain of RecQ helicase from the bacterium Cronobacter sakazakii.

    • Andrew F. Voter
    • Yupeng Qiu
    • James L. Keck
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8