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Showing 1–42 of 42 results
Advanced filters: Author: Randy J Seeley Clear advanced filters
  • Many people with obesity and type 2 diabetes achieve remission of their diabetes after Roux-en-Y gastric bypass surgery, but the mechanisms of remission remain disputed. We provide our perspective on competing datasets that point towards this effect being due either entirely to the loss of weight or to weight loss-independent effects.

    • Samuel Klein
    • Randy J. Seeley
    Reviews
    Nature Metabolism
    Volume: 5, P: 912-914
  • Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are the most effective therapy for the treatment of obesity; now bile acids, and the presence of the nuclear bile acid receptor FXR, are shown to underpin the mechanism of VSG action, and the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced if FXR is absent.

    • Karen K. Ryan
    • Valentina Tremaroli
    • Randy J. Seeley
    Research
    Nature
    Volume: 509, P: 183-188
  • The intestinal bacteria in obese humans and mice differ from those in lean individuals. Are these bacteria involved in how we regulate body weight, and are they a factor in the obesity epidemic?

    • Matej Bajzer
    • Randy J. Seeley
    News & Views
    Nature
    Volume: 444, P: 1009-1010
  • Bariatric surgery is an effective weight-loss strategy and often results in remission of type 2 diabetes mellitus (T2DM); still, how this surgery affects T2DM is unknown. A new study suggests that fibroblast growth factor 19 and bile acids are involved in remission of T2DM after bariatric surgery.

    • Rohit Kohli
    • Randy J. Seeley
    News & Views
    Nature Reviews Endocrinology
    Volume: 9, P: 572-574
  • In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as by increasing insulin sensitivity.

    • Frederike Sass
    • Tao Ma
    • Zachary Gerhart-Hines
    ResearchOpen Access
    Nature
    Volume: 635, P: 987-1000
  • Many people smoke to keep their weight down. The identification of the molecular target in the brain for the appetite-suppressant effects of nicotine is a first step towards finding healthy alternatives to smoking for weight management.

    • Randy J. Seeley
    • Darleen A. Sandoval
    News & Views
    Nature
    Volume: 475, P: 176-177
  • The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food intake or exercise motivation.

    • Anders B. Klein
    • Trine S. Nicolaisen
    • Christoffer Clemmensen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9
  • A recent study has shown that a single dose of fibroblast growth factor (FGF) 1 into the central nervous system (CNS) of various mouse and rat models of type 2 diabetes results in profound and exceptionally long-lasting reductions in blood glucose. This work raises the possibility of truly revolutionary therapies for individuals with type 2 diabetes that target the brain FGF system.

    • Randy J Seeley
    • Darleen A Sandoval
    News & Views
    Nature Medicine
    Volume: 22, P: 709-711
  • Interactions between the immune system and adipose tissue contribute to the regulation of body weight, however, the underlying mechanisms remain incompletely understood. Here the authors dissect the role of two structurally and functionally similar immune mediators, BAFF and APRIL, in modifying diet-induced weight gain and adipocyte lipid handling.

    • Calvin C. Chan
    • Isaac T. W. Harley
    • Senad Divanovic
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • Although the use of thiazolidinediones in the treatment of type 2 diabetes is controversial, they still comprise an important class of insulin-sensitizing drugs. In two reports, new evidence emerges that these drugs rely on the activation of their target, PPAR-A, in the brain to improve hepatic insulin sensitivity and increase food intake and reduce energy expenditure.

    • Karen K Ryan
    • Bailing Li
    • Randy J Seeley
    Research
    Nature Medicine
    Volume: 17, P: 623-626
  • The authors of this Review integrate contributions of both central and peripheral glucagon-like peptide 1 (GLP-1), which is secreted from the intestine in response to nutrient ingestion, in a model of short-term and long-term control of energy balance. This model is discussed with respect to current GLP-1-based therapies and ongoing research that may help maximize the effectiveness of GLP-1-based treatment of obesity.

    • Jason G. Barrera
    • Darleen A. Sandoval
    • Randy J. Seeley
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 507-516
  • Mice possess neurons in the preoptic area of the hypothalamus that are sensitive to violet light; these deep brain neurons sense light via OPN5 and regulate adaptive thermogenesis in brown fat.

    • Kevin X. Zhang
    • Shane D’Souza
    • Richard A. Lang
    Research
    Nature
    Volume: 585, P: 420-425
  • One effect of weight-loss surgery is a change in food preferences. An analysis in rats shows that this is caused by altered nutrient signals in the intestine. These activate the vagus nerve to increase signalling in the brain by the neurotransmitter dopamine.

    • Darleen A. Sandoval
    • Randy J. Seeley
    News & Views
    Nature
    Volume: 542, P: 302-303
  • Treatment with a neuronal growth factor stimulates weight loss—and spurs the development of new neurons that help maintain reduced weight.

    • Randy J Seeley
    News & Views
    Nature Medicine
    Volume: 11, P: 1276-1278
  • The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via protection against bile acid toxicity.

    • Nadejda Bozadjieva-Kramer
    • Jae Hoon Shin
    • Randy J. Seeley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19
  • Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeostasis after to gastric bypass surgery, and report that improved glycemia was mediated by the growth hormone receptor.

    • Jonathan M. Dreyfuss
    • Yixing Yuchi
    • Mary Elizabeth Patti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • A spate of recent studies has identified key neural pathways that control glucose production from the liver. They may provide a new link between obesity and type 2 diabetes.

    • Randy J Seeley
    • Matthias Tschöp
    News & Views
    Nature Medicine
    Volume: 12, P: 47-49
  • Sandoval and colleagues discuss emerging evidence for a role of the CNS in the regulation of glucose homeostasis and show that this regulation involves several neural circuits and mechanisms that also control energy balance. Disruption of these overlapping pathways may link the metabolic impairments that are associated with obesity and type 2 diabetes.

    • Bernadette E. Grayson
    • Randy J. Seeley
    • Darleen A. Sandoval
    Reviews
    Nature Reviews Neuroscience
    Volume: 14, P: 24-37
  • The growing appreciation of the regulatory role of the central nervous system (CNS) in energy and glucose homeostasis has the potential to lead to more effective long–term treatments for obesity and type 2 diabetes. Here, Sandoval and colleagues discuss the CNS pathways involved, identify promising therapeutic targets and strategies for diabetes and consider the associated challenges hampering the development of new agents.

    • Darleen A. Sandoval
    • Silvana Obici
    • Randy J. Seeley
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 386-398
  • New research shows that a drug conjugate that links the dual PPAR𝛼/𝛾 agonist tesaglitazar to a GLP-1 receptor agonist has superior effects on weight loss and glucose metabolism compared with monotherapy in mice. The conjugate has actions in the hypothalamus that may contribute to its benefits.

    • Randy J. Seeley
    • Christopher J. Rhodes
    News & Views
    Nature Metabolism
    Volume: 4, P: 965-966
  • Fat cells secrete the hormone adiponectin, which regulates glucose metabolism through actions on peripheral tissues. It is now apparent that adiponectin also acts on the brain to reduce body weight and improve glucose metabolism (pages 524–529).

    • Randy J Seeley
    • David A D'Alessio
    • Stephen C Woods
    News & Views
    Nature Medicine
    Volume: 10, P: 454-455
  • Estrogen is beneficial for obesity and type 2 diabetes, though its use is limited by important side effects. In a new study, Matthias Tschöp and colleagues avoid this issue by chemically linking estrogen to the hormone GLP-1 to selectively target metabolically relevant tissue and show that the conjugated compound corrects obesity, hyperglycemia and dyslipidemia in mice. This approach could be used for other hormone pairs to treat other diseases.

    • Brian Finan
    • Bin Yang
    • Matthias H Tschöp
    Research
    Nature Medicine
    Volume: 18, P: 1847-1856
  • The hindbrain is mostly known to participate in eating behaviour by controlling short-term meal parameters and aversive responses to gut malaise. Cheng et al. review current evidence revealing non-aversive neuronal circuits in the hindbrain that are relevant for initiation and termination of homeostatic feeding, as well as for the long-term control of body weight.

    • Wenwen Cheng
    • Desiree Gordian
    • Martin G. Myers Jr.
    Reviews
    Nature Metabolism
    Volume: 4, P: 826-835
  • An alternative view of diabetes is presented in which blood glucose homeostasis is achieved via collective actions of two regulatory systems: a brain-centred glucoregulatory system (BCGS), which works together with the pancreatic islets; defects in both systems may be required for diabetes to occur, and interventions targeting both systems may have greater therapeutic potential.

    • Michael W. Schwartz
    • Randy J. Seeley
    • David D’Alessio
    Reviews
    Nature
    Volume: 503, P: 59-66
  • Energy balance is maintained by neuronal populations throughout the central nervous system, but is primarily localized in the mediobasal hypothalamus. In this review, the authors discuss recent work examining plastic changes in hypothalamic circuits in response changes in nutrient availability and long-term energy status.

    • Lori M Zeltser
    • Randy J Seeley
    • Matthias H Tschöp
    Reviews
    Nature Neuroscience
    Volume: 15, P: 1336-1342
  • Coordination between peripheral signals that reflect feeding status and central regulatory mechanisms are crucial for regulating body weight. In this Review, Sandoval and colleagues discuss how and where peripherally derived signals are integrated within the CNS to modulate feeding behaviour.

    • Ki-Suk Kim
    • Randy J. Seeley
    • Darleen A. Sandoval
    Reviews
    Nature Reviews Neuroscience
    Volume: 19, P: 185-196