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Showing 1–3 of 3 results
Advanced filters: Author: Ranganath Gopalakrishnan Clear advanced filters

  • Enhancing the sp3-hybridized character of molecular structures in drug discovery is paramount. Here, the authors introduce a deoxygenative cross-electrophile coupling technique that pairs easily accessible carboxylic acid-derived redox-active esters with aldehyde sulfonyl hydrazones, employing Eosin Y as an organophotocatalyst under visible light irradiation.

    • Stefano Bonciolini
    • Antonio Pulcinella
    • Timothy Noël
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.

    • Hélène Adihou
    • Ranganath Gopalakrishnan
    • Herbert Waldmann
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Disulfide bonds formed between two cysteine residues are important in the folding and stability of proteins. Now, unnatural amino acids with side-chains that contain two thiol groups are described. Incorporation of these dithiol amino acids into a serine protease inhibitor and a nicotinic acetyl choline receptor antagonist is shown to increase their inhibitory activity.

    • Shiyu Chen
    • Ranganath Gopalakrishnan
    • Christian Heinis
    Research
    Nature Chemistry
    Volume: 6, P: 1009-1016