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Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus-conditioned media

Panjana Sengprasert
Palapun Waitayangkoon
Rangsima Reantragoon
ResearchOpen Access05 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes

Srihatach Ngarmukos
Chotetawan Tanavalee
Aree Tanavalee
ResearchOpen Access08 Dec 2021
Scientific Reports

Volume: 11, P: 1-10
Recognition of vitamin B metabolites by mucosal-associated invariant T cells

T-cell receptors expressed on mucosal-associated invariant T cells function in a similar manner to innate immune receptors by recognizing small molecules such as microbial metabolites. Here, the authors report structures of this receptor in complex with vitamin B metabolites presented by the MHC-like protein MR1.

Onisha Patel
Lars Kjer-Nielsen
Jamie Rossjohn
Research11 Jul 2013
Nature Communications

Volume: 4, P: 1-9
MR1 presents microbial vitamin B metabolites to MAIT cells

The structure of the major histocompatibility complex (MHC)-class-I-like molecule MR1 in complex with a vitamin B9 derivative is determined; metabolites of vitamin B2 are shown to activate MR1-restricted mucosal-associated invariant T cells, implicating them in microbial immunosurveillance.

Lars Kjer-Nielsen
Onisha Patel
James McCluskey
Research10 Oct 2012
Nature

Volume: 491, P: 717-723
T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Activation of mucosal-associated invariant T (MAIT) cells is shown to require key genes encoding an early intermediate in bacterial riboflavin synthesis, 5-amino-6-d-ribitylaminouracil; this reacts non-enzymatically with metabolites to form short-lived antigens that are captured and stabilized by MR1 for presentation to MAIT cells.

Alexandra J. Corbett
Sidonia B. G. Eckle
James McCluskey
Research02 Apr 2014
Nature

Volume: 509, P: 361-365
Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8

Pattarin Tangtanatakul
Boonyakiat Thammasate
Nattiya Hirankarn
ResearchOpen Access06 Nov 2017
Scientific Reports

Volume: 7, P: 1-18

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Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus-conditioned media

Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

MR1 presents microbial vitamin B metabolites to MAIT cells

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8

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Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus-conditioned media

Two or four injections of platelet-rich plasma for osteoarthritic knee did not change synovial biomarkers but similarly improved clinical outcomes

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

MR1 presents microbial vitamin B metabolites to MAIT cells

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8

Search

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