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Showing 1–4 of 4 results
Advanced filters: Author: Raphael P. B. Jacquat Clear advanced filters
  • Physical characterisation of proteins is challenging. Here the authors report single-molecule microfluidic diffusional sizing (smMDS) to enable calibration-free single-molecule diffusional-sizing based monitoring of protein hydrodynamic radii even within heterogenous multicomponent mixtures.

    • Georg Krainer
    • Raphael P. B. Jacquat
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • The formation of protein aggregates is a hallmark of Parkinson’s disease, with small oligomeric species implicated as a major source of toxicity. In this work, Xu et al. determine their mechanism of formation and role in aggregation.

    • Catherine K. Xu
    • Georg Meisl
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • The underlying mechanism for how heterotypic protein–RNA interactions modulate the liquid to amyloid transition of hnRNPA1A, a protein involved in amyotrophic lateral sclerosis, has so far remained elusive. Now characterization of hnRNPA1A condensate formation and aggregation in vitro reveals that the RNA/protein stoichiometry affects the molecular pathways leading to amyloid formation.

    • Chiara Morelli
    • Lenka Faltova
    • Paolo Arosio
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 1052-1061
  • There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in a single, solution-phase step.

    • Georg Krainer
    • Kadi L. Saar
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21