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Showing 1–7 of 7 results
Advanced filters: Author: Raphael Reher Clear advanced filters

  • Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.

    • Raphael Reher
    • Allegra T. Aron
    • Daniel Petras
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The Mass Spectrometry Query Language (MassQL) is an open-source language that enables instrument-independent searching across mass spectrometry data for complex patterns of interest via concise and expressive queries without the need for programming skills.

    • Tito Damiani
    • Alan K. Jarmusch
    • Mingxun Wang
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 1247-1254

  • Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable to act as genuine signal initiators.

    • Manuel Grundmann
    • Nicole Merten
    • Evi Kostenis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Advances in computational omics technologies are enabling access to the hidden diversity of natural products, and artificial intelligence approaches are facilitating key steps in harnessing the therapeutic potential of such compounds, including biological activity prediction. This article discusses synergies between these fields to effectively identify drug candidates from the plethora of molecules produced by nature, and how to address the challenges in realizing the potential of these synergies.

    • Michael W. Mullowney
    • Katherine R. Duncan
    • Marnix H. Medema
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 895-916

  • Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

    • Michelle A. Schorn
    • Stefan Verhoeven
    • Justin J. J. van der Hooft
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 17, P: 363-368