Nature Search

Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques

Long non-coding RNAs (lncRNAs) play key roles in the immune response but their properties at the single-cell level are less well understood. Here, the authors characterize differential features of lncRNAs and protein-coding genes upon Ebola infection in macaques at single-cell resolution.

Luisa Santus
Maria Sopena-Rios
Marta Melé
ResearchOpen Access30 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

Comparative epigenomics has revealed principles underlying the evolution of gene expression regulation, and the integration of epigenomic data is important for a deeper understanding of this evolution. Here the authors report the evolutionary dynamics of the epigenomic regulatory landscape in primates and their impact in recent human evolution.

Raquel García-Pérez
Paula Esteller-Cucala
Tomàs Marquès-Bonet
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-17
Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Asexual vertebrates are extremely rare. Here, the authors sequence the genome of the Amazon molly, an asexual fish, and find few signs of genetic degeneration but clonal polymorphism and high heterozygosity, which might explain the success of this species.

Wesley C. Warren
Raquel García-Pérez
Manfred Schartl
ResearchOpen Access12 Feb 2018
Nature Ecology & Evolution

Volume: 2, P: 669-679
Differential DNA methylation of vocal and facial anatomy genes in modern humans

How traits specific to modern humans have evolved is difficult to study. Here, Gokhman et al. compare measured and reconstructed DNA methylation maps of present-day humans, archaic humans and chimpanzees and find that genes that affect vocal tract and facial anatomy show methylation changes between archaic and modern humans.

David Gokhman
Malka Nissim-Rafinia
Liran Carmel
ResearchOpen Access04 Mar 2020
Nature Communications

Volume: 11, P: 1-21
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Rodin and Dou et al. characterized genome-wide somatic mutation in autistic and control brains, revealing that even unaffected individuals may possess dozens of brain somatic mutations and providing insight into the role of somatic mutation in autism.

Rachel E. Rodin
Yanmei Dou
Christopher A. Walsh
Research11 Jan 2021
Nature Neuroscience

Volume: 24, P: 176-185
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Rachel E. Rodin
Yanmei Dou
Christopher A. Walsh
Amendments and Corrections29 Aug 2023
Nature Neuroscience

Volume: 26, P: 1833
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Rachel E. Rodin
Yanmei Dou
Christopher A. Walsh
Amendments and Corrections22 Mar 2021
Nature Neuroscience

Volume: 24, P: 611
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Jair Tenorio
Pablo Alarcón
Pablo Lapunzina
Research04 Nov 2019
European Journal of Human Genetics

Volume: 28, P: 469-479
Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis

Maite Calucho
Silvia Gartner
Eduardo F. Tizzano
ResearchOpen Access30 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients

Diego A. Rodríguez-Serrano
Emilia Roy-Vallejo
Jesús Delgado Valdueza
ResearchOpen Access23 Jun 2021
Scientific Reports

Volume: 11, P: 1-11

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Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques

Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Differential DNA methylation of vocal and facial anatomy genes in modern humans

The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing

Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Validation of nasospheroids to assay CFTR functionality and modulator responses in cystic fibrosis

Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients

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