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Showing 1–6 of 6 results
Advanced filters: Author: Rashid Akbergenov Clear advanced filters

  • In this paper, translation fidelity was assessed across aging in knock-in mice with a mistranslation reporter which determines stop codon readthrough. Age-related increases in translational errors were observed in muscle and brain, but not in liver, highlighting organ-dependent declines in translation fidelity as a possible contributor to aging.

    • Erik C. Böttger
    • Harshitha Santhosh Kumar
    • Rashid Akbergenov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Aminoglycoside antibiotics target the ribosome but their limited selectivity for the bacterial ribosome can cause side effects in humans. Here, the authors synthesize 4′-O-ether or 4′,6′-O-acetal modifications and show that these compounds possess increased selectivity against bacterial ribosomes.

    • Déborah Perez-Fernandez
    • Dmitri Shcherbakov
    • Erik C. Böttger
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11

  • Sanchón et al find that misfolded proteins formed in the ER can become associated with mitochondria, both in mammalian cells and in yeast, resulting in impaired mitochondrial function. They further discover that components of ERMES-mediated ER-mitochondria contacts are needed for this mechanism, which they name ERAMS, for ER-associated mitochondrial sequestration.

    • Adrián Cortés Sanchón
    • Harshitha Santhosh Kumar
    • Erik C. Böttger
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13

  • Shcherbakov et al. investigate the consequences of ribosome mistranslation in human cells, by expressing a mutant version of the small ribosomal subunit protein RPS2. They observe activation of protein quality control pathways, but also increased mitochondrial biogenesis and silencing of the unfolded protein response in the endoplasmic reticulum.

    • Dmitri Shcherbakov
    • Youjin Teo
    • Erik C. Böttger
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-16

  • By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the pathological changes observed in age-related diseases, such as muscle atrophy

    • James Moore
    • Rashid Akbergenov
    • Erik C. Böttger
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11