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Advanced filters: Author: Rasmus Berglund Clear advanced filters

The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34

Microglia could have health-promoting capacities in age-associated neuroinflammation. Here, the authors describe an autophagy and IL-34 dependent neuroprotective microglia population in the aging brain as a potential therapeutic target.

Rasmus Berglund
Yufei Cheng
Maja Jagodic
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Harris and colleagues show that the cytokine TGF-β is required for colonization of the microglial niche and maintenance of central nervous system integrity. Acute loss of TGF-β leads to proinflammatory responses and fatal demyelinating disease.

Harald Lund
Melanie Pieber
Robert A. Harris
Research16 Apr 2018
Nature Immunology

Volume: 19, P: 1-7

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The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

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