Low body mass index (BMI) is associated with increased brain metastasis risk in lung cancer patients. Here, the authors report that low-BMI increases neuronal secretion of neuropeptide Y (NPY), thereby activating the NPY receptor on lung tumor cells, leading to tumor metabolic reprogramming and brain metastasis.
- Abhishek Tyagi
- Shih-Ying Wu
- Kounosuke Watabe
