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Showing 1–4 of 4 results
Advanced filters: Author: Ray Lowery Clear advanced filters
  • In an iterative phase 2 trial, patients with metastatic, treatment-refractory, mismatch repair proficient gastrointestinal cancers had responses to neoantigen-reactive tumor-infiltrating lymphocytes but not bulk tumor-infiltrating lymphocytes, highlighting the potential for a refined immune cell therapy approach in this patient population.

    • Frank J. Lowery
    • Stephanie L. Goff
    • Steven A. Rosenberg
    Research
    Nature Medicine
    Volume: 31, P: 1994-2003
  • Preliminary findings in seven patients with mismatch repair-proficient metastatic colorectal cancer who were treated in the context of a phase 2 trial show that adoptive transfer of autologous peripheral blood T lymphocytes that were retrovirally transduced with personalized neoantigen-reactive T cell receptors can be safe and induce early clinical responses.

    • Maria Parkhurst
    • Stephanie L. Goff
    • Steven A. Rosenberg
    Research
    Nature Medicine
    Volume: 30, P: 2586-2595
  • This is a ductal-dependent lesion and the baby will need prostaglandin infusion to maintain a patent ductus arteriosus to provide systemic blood flow. Given that the lesion is ductal dependent,we would recommend neonatology attendance at delivery with initial stabilization and treatment of the infant in the NEST (Newborn Evaluation, Stabilization, and Treatment Room) with prostaglandin initiation, umbilical line placement and an echocardiogram prior to admission to the PCTU (Pediatric Cardiothoracic ICU). We anticipate that the baby will be stable from a cardiovascular standpoint at delivery and for a short time thereafter as the ductus arteriosus will be open. Initial oxygen saturations above 75% are acceptable for this heart lesion. Therefore, if the baby appears well in the delivery room we would encourage a lot of family a brief period of time for appearance parent-baby bonding either before initial assessment in the NEST or after initial assessment in the NEST and prior to line placement.

    • Ian Thomas
    • Naomi T. Laventhal
    • Sarah Gelehrter
    Research
    Journal of Perinatology
    Volume: 40, P: 1531-1536