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Showing 1–4 of 4 results
Advanced filters: Author: Raymond Carragher Clear advanced filters

  • Analysis of 1.32 billion records of medication data from England, Scotland and Wales reveals that the COVID-19 pandemic led to substantial declines in dispensing of antihypertensive and lipid-lowering medications, leading to increased risks for future cardiovascular disease.

    • Caroline E. Dale
    • Rohan Takhar
    • Reecha Sofat
    Research
    Nature Medicine
    Volume: 29, P: 219-225

  • Designed β-strand peptides stabilize integral membrane proteins for biochemical and structural studies, enabling electron microscopy analysis of the dynamic conformations of the ABC transporter MsbA.

    • Houchao Tao
    • Sung Chang Lee
    • Qinghai Zhang
    Research
    Nature Methods
    Volume: 10, P: 759-761

  • G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins in humans and exhibit diverse activation mechanisms. Here, the authors combine electron microscopy, hydrogen deuterium exchange and Molecular dynamics simulations to gain insight into the activation mechanism of the glucagon receptor.

    • Linlin Yang
    • Dehua Yang
    • Hualiang Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • G protein-coupled receptors are a large family of signalling proteins that mediate cellular responses primarily via G proteins or arrestins, and they are targets of one-third of the current clinically used drugs; here, an active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin-1 is determined, revealing unique structural features that may constitute essential elements for arrestin-biased signalling.

    • Yanyong Kang
    • X. Edward Zhou
    • H. Eric Xu
    Research
    Nature
    Volume: 523, P: 561-567