Optogenetic activation of β2-adrenergic receptors (β2-AR) has been achieved, but not characterized in detail. Here, Siudaet al. show that light-controlled opto-β2AR mimics endogenous β2AR activity in vitro and in vivo, and develop novel, optically active, functionally selective receptors to bias β2AR intracellular signaling mechanisms.
- Edward R. Siuda
- Jordan G. McCall
- Michael R. Bruchas
