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Showing 1–5 of 5 results
Advanced filters: Author: Rebecca Cardone Clear advanced filters

  • Retrovirus capsids are polymorphic, consisting of variable hexamer and pentamer aggregates that are thought to reflect fullerenes. This paper reports the cryo-electron microscopy analysis of RSV capsid protein visualizing pentamers, and confirms that retrovirus capsid has a fullerene-based architecture.

    • Giovanni Cardone
    • John G. Purdy
    • Alasdair C. Steven
    Research
    Nature
    Volume: 457, P: 694-698

  • The use of sodium-glucose transport protein 2 (SGLT2) inhibitors for the treatment of diabetes has been associated with euglycemic ketoacidosis and increased glucose production and glucagon secretion. Here Perry et al. show that these effects rely on both insulinopenia and dehydration, and thus suggest ways to manage the side effects associated with the use of SGLT2 inhibitors.

    • Rachel J. Perry
    • Aviva Rabin-Court
    • Gerald I. Shulman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Increased acetate production by an altered gut microbiota in rats fed a high-fat diet activates the parasympathetic nervous system, which in turn promotes increased insulin secretion, increased food intake, obesity and related changes.

    • Rachel J. Perry
    • Liang Peng
    • Gerald I. Shulman
    Research
    Nature
    Volume: 534, P: 213-217

  • Exome sequencing identifies loss-of-function CELA2A mutations in families with early-onset atherosclerosis and metabolic syndrome. Functional studies show that CELA2A is a circulating enzyme that reduces platelet activation, triggers insulin secretion and degradation, and increases insulin sensitivity.

    • Fatemehsadat Esteghamat
    • James S. Broughton
    • Arya Mani
    Research
    Nature Genetics
    Volume: 51, P: 1233-1243