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Showing 1–3 of 3 results
Advanced filters: Author: Rebecca Ebenhoch Clear advanced filters

  • Endogenous activation of lipid GPCRs can be mediated by membrane components. Here, authors show an orthosteric binding site opens towards the membrane, setting the foundation for structure-based development of drugs targeting GPR55.

    • Tobias Claff
    • Rebecca Ebenhoch
    • Dietmar Weichert
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Myeloid-derived growth factor (MYDGF) is an angiogenic growth factor with therapeutic potential for ischemic tissue repair and the receptor is still unknown. Here the authors present the crystal structure of human MYDGF and identify its functional epitope through mutagenesis studies.

    • Rebecca Ebenhoch
    • Abbas Akhdar
    • Herbert Nar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Structural and biochemical investigation on GPR180, which is as a new member of the Golgi dynamics domain seven-transmembrane helix (GOST) protein family, due to its intracellular localization and a potential pH-dependent effect on its conformation.

    • Sarah-Ana Mitrovic
    • Chamalee Demalgiriya-Gamage
    • Herbert Nar
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-14