Organometallic reagents are widely used as nucleophiles in asymmetric catalysis. Here, alkylmetal species generated in situ by hydrometallation of alkenes are used in enantioselective copper-catalysed C–C bond formation. The process is formally an asymmetric reductive coupling of an alkene to an enone, and tolerates many functional groups.
- Rebecca M. Maksymowicz
- Philippe M. C. Roth
- Stephen P. Fletcher
