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Showing 1–7 of 7 results
Advanced filters: Author: Rebecca Scheel Clear advanced filters

  • Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.

    • Michael Grigalunas
    • Annina Burhop
    • Herbert Waldmann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific members of the chromosome 19 microRNA cluster.

    • Alexander Beck
    • Lisa Gabler-Pamer
    • Mariella G. Filbin
    ResearchOpen Access
    Nature Cancer
    Volume: 6, P: 1035-1055

  • There is increasing evidence of a functional interaction between acute myeloid leukemia (AML) and immune cells, influencing disease outcome. Here the authors study how distinct oncogenes differentially affect the host immune response to leukemic cells in preclinical models of AML.

    • Rebecca J. Austin
    • Jasmin Straube
    • Megan J. Bywater
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • To address the question of whether a recurrent tumour is genetically similar to the tumour at diagnosis, the evolution of medulloblastoma has been studied in both an in vivo mouse model of clinical tumour therapy as well as in humans with recurrent disease; targeted tumour therapies are usually based on targets present in the tumour at diagnosis but the results from this study indicate that post-treatment recurring tumours (compared with the tumour at diagnosis) have undergone substantial clonal divergence of the initial dominant tumour clone.

    • A. Sorana Morrissy
    • Livia Garzia
    • Michael D. Taylor
    Research
    Nature
    Volume: 529, P: 351-357

  • Michael Taylor, Marco Marra and colleagues analyze spatial tumor heterogeneity in 9 medulloblastomas, 16 high-grade gliomas and 10 renal cell carcinomas, using a combination of transcriptomic and genomic profiling of multiregional biopsies. They find that medulloblastomas have spatially homogeneous transcriptomes, whereas somatic mutations that affect genes suitable for targeted therapeutics are spatially heterogeneous.

    • A Sorana Morrissy
    • Florence M G Cavalli
    • Michael D Taylor
    Research
    Nature Genetics
    Volume: 49, P: 780-788