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Showing 1–4 of 4 results

Advanced filters: Author: Reetakshi Arora Clear advanced filters

Identification of bacteria-derived HLA-bound peptides in melanoma

HLA peptidomic analysis identifies recurrent intracellular bacteria-derived peptides presented on HLA-I and HLA-II molecules in melanoma tumours, revealing how bacteria can modulate immune functions and responses to cancer therapies.

Shelly Kalaora
Adi Nagler
Yardena Samuels
Research17 Mar 2021
Nature

Volume: 592, P: 138-143
A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

Conserved microbiome features across clinical and geographical variations may enable microbiome-based predictions of outcomes in CD19-targeted CAR-T cell immunotherapy

Christoph K. Stein-Thoeringer
Neeraj Y. Saini
Eran Elinav
Research13 Mar 2023
Nature Medicine

Volume: 29, P: 906-916
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Clinical benefit or intestinal toxicity resulting from combined immune checkpoint blockade in patients with melanoma associates with prevalent commensal bacteria and can be decoupled by IL-1R inhibition.

Miles C. Andrews
Connie P. M. Duong
Jennifer A. Wargo
Research08 Jul 2021
Nature Medicine

Volume: 27, P: 1432-1441
B cells and tertiary lymphoid structures promote immunotherapy response

Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response.

Beth A. Helmink
Sangeetha M. Reddy
Jennifer A. Wargo
Research15 Jan 2020
Nature

Volume: 577, P: 549-555