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GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers

Through a CRISPR-activation screen, Ravid Lustig et al. show that GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate X chromosome inactivation in early mouse embryos.

Liat Ravid Lustig
Abhishek Sampath Kumar
Edda G. Schulz
ResearchOpen Access06 Nov 2023
Nature Cell Biology

Volume: 25, P: 1704-1715
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases

Frameshift mutations that create arginine-rich basic tails in transcription factors and other proteins can lead to altered phase separation in the nucleolus, which in turn leads to syndromes such as brachyphalangy, polydactyly and tibial aplasia.

Martin A. Mensah
Henri Niskanen
Denes Hnisz
ResearchOpen Access08 Feb 2023
Nature

Volume: 614, P: 564-571
Hijacking of transcriptional condensates by endogenous retroviruses

TRIM28 depletion in embryonic stem cells disconnects transcriptional condensates from super-enhancers, which is rescued by knockdown of endogenous retroviruses.

Vahid Asimi
Abhishek Sampath Kumar
Denes Hnisz
ResearchOpen Access21 Jul 2022
Nature Genetics

Volume: 54, P: 1238-1247
Dnmt1 has de novo activity targeted to transposable elements

The canonical DNA methylation maintenance enzyme Dnmt1 displays global de novo methylation activity with greater targeting towards IAP transposons, which may contribute to their stable repression during early development.

Chuck Haggerty
Helene Kretzmer
Alexander Meissner
ResearchOpen Access17 Jun 2021
Nature Structural & Molecular Biology

Volume: 28, P: 594-603
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

Rosebrock, Arora et al. report a method to overcome limited cortical cellular diversity in human organoids, thus mirroring fundamental features of cortical development and offering a basis for organoid-based disease modelling.

Daniel Rosebrock
Sneha Arora
Yechiel Elkabetz
ResearchOpen Access13 Jun 2022
Nature Cell Biology

Volume: 24, P: 981-995

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GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers

Aberrant phase separation and nucleolar dysfunction in rare genetic diseases

Hijacking of transcriptional condensates by endogenous retroviruses

Dnmt1 has de novo activity targeted to transposable elements

Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells

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