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Showing 1–8 of 8 results
Advanced filters: Author: Renato Bruni Clear advanced filters

  • Xkr4 apoptotic scramblase activation is thought to involve caspase cleavage and dimerization to expose phosphatidylserine on dying cells. The authors show that full-length Xkr4 is an active monomeric scramblase. CryoEM reveals a conformation that promotes membrane thinning and scrambling, enhancing understanding of hXkr4 activity.

    • Sayan Chakraborty
    • Zhang Feng
    • Alessio Accardi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • SLAC1 is a plant ion channel that controls turgor pressure in the guard cells of plant stomata, thereby regulating the exchange of water vapour and photosynthetic gases in response to environmental signals. Here, the X-ray crystal structure of a bacterial homologue of SLAC1 has been solved, and structure-inspired mutagenesis has been used to analyse the conductance properties of the channel. The findings indicate that selectivity among different anions is largely a function of the energetic cost of ion dehydration.

    • Yu-hang Chen
    • Lei Hu
    • Wayne A. Hendrickson
    Research
    Nature
    Volume: 467, P: 1074-1080

  • Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaining molecular insight into TRICs’ function.

    • Min Su
    • Feng Gao
    • Yu-hang Chen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Polyisoprenyl-glycosyltransferases (PI-GTs) catalyse the addition of sugar to lipid carriers, which is the first step in the production of sugar donors for glycosylation. Here Ardiccioni et al.present the structure of a bacterial PI-GT and propose a mechanistic basis for sugar transfer.

    • Chiara Ardiccioni
    • Oliver B. Clarke
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Here, the X-ray crystal structure of TrkH is solved, a protein that mediates potassium uptake in Vibrio parahaemolyticus, a bacterium. The selectivity filter of the ion transporter is very similar to what is seen in (much simpler) potassium ion channels, but it is significantly shorter. Biochemical studies were performed to explore the molecular basis of K+ selectivity, and it is believed that a novel gating mechanism is involved.

    • Yu Cao
    • Xiangshu Jin
    • Ming Zhou
    Research
    Nature
    Volume: 471, P: 336-340