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Erratum: Themis, a T cell–specific protein important for late thymocyte development

Renaud Lesourne
Shoji Uehara
Paul E Love
Amendments and Corrections01 Jan 2010
Nature Immunology

Volume: 11, P: 97
Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1

Seeyoung Choi
Claude Warzecha
Paul E Love
Amendments and Corrections18 May 2017
Nature Immunology

Volume: 18, P: 705
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation

Here, the authors use a double-reporter system to tag IFNγ-producing versus IL-17A-producing γδ T cells to compile a trancriptomic resource of these cell subsets in mice at steady state and in response to cerebral malaria or multiple sclerosis.

Daniel Inácio
Tiago Amado
Bruno Silva-Santos
ResearchOpen Access29 Jan 2025
Nature Immunology

Volume: 26, P: 497-510
THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1

Love and colleagues show that THEMIS enhances the TCR signaling response to low-affinity ligands by inhibiting the tyrosine-phosphatase activity of SHP-1.

Seeyoung Choi
Claude Warzecha
Paul E Love
Research27 Feb 2017
Nature Immunology

Volume: 18, P: 433-441
Themis, a T cell–specific protein important for late thymocyte development

The molecular mechanisms that underpin thymocyte selection remain incompletely defined. Groups led by Love, Gascoigne and Schwartz independently identify Themis, a signaling protein essential for the positive selection of thymocytes.

Renaud Lesourne
Shoji Uehara
Paul E Love
Research13 Jul 2009
Nature Immunology

Volume: 10, P: 840-847
TCR ITAM multiplicity is required for the generation of follicular helper T-cells

The strength of TCR activation shapes T cell selection and differentiation. Here the authors show by modulating the number of activatory motifs in TCR complex that the strength of TCR signal is critical for the development of some T cell subsets but not for T cell effector functions or repertoire.

SuJin Hwang
Amy C. Palin
Paul E. Love
ResearchOpen Access11 May 2015
Nature Communications

Volume: 6, P: 1-13
Themis2 lowers the threshold for B cell activation during positive selection

Cornall and colleagues show that Themis2 interacts with the phospholipase PLC-γ2 and lowers the threshold for B cell activation by low but not high avidity antigens.

Daian Cheng
Mukta Deobagkar-Lele
Richard J Cornall
Research19 Dec 2016
Nature Immunology

Volume: 18, P: 205-213
Regulatory mechanisms in T cell receptor signalling

This Review discusses the latest insights into the mechanisms regulating T cell receptor (TCR) signalling responses. In particular, the authors focus on how TCR signalling is regulated during thymocyte selection and during T cell homeostasis.

Guillaume Gaud
Renaud Lesourne
Paul E. Love
Reviews22 May 2018
Nature Reviews Immunology

Volume: 18, P: 485-497

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