Nature Search

Light-induced changes of the subretinal space of the temporal retina observed via optical coherence tomography

Alina Messner
René M. Werkmeister
Valentin Aranha dos Santos
ResearchOpen Access20 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
Stability of O₂/H₂ mixtures at high pressure

Paul Loubeyre
René LeToullec
Research02 Nov 1995
Nature

Volume: 378, P: 44-46
MICU1 controls cristae junction and spatially anchors mitochondrial Ca²⁺ uniporter complex

Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca²⁺ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.

Benjamin Gottschalk
Christiane Klec
Wolfgang F. Graier
ResearchOpen Access19 Aug 2019
Nature Communications

Volume: 10, P: 1-17
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca²⁺ uptake in immortalized cells

MICU1 is a regulatory subunit of mitochondrial Ca²⁺ channels that shields mitochondria from Ca²⁺ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca²⁺ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca²⁺uptake activity.

Corina T. Madreiter-Sokolowski
Christiane Klec
Wolfgang F. Graier
ResearchOpen Access19 Sept 2016
Nature Communications

Volume: 7, P: 1-13
Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics

Nitric oxide is a volatile free radical second messenger with a large number of biological effects. Here Eroglu et al. develop genetically encoded fluorescent biosensors for nitric oxide and use them to visualise subcellular nitric oxide dynamics in single cells.

Emrah Eroglu
Benjamin Gottschalk
Roland Malli
ResearchOpen Access04 Feb 2016
Nature Communications

Volume: 7, P: 1-11
Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

K⁺ plays an important role in physiology and disease, but the lack of high specificity K⁺ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K⁺ concentration in body fluids, cells and specific organelles.

Helmut Bischof
Markus Rehberg
Roland Malli
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-12
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development

Interleukin 7 (IL-7) signaling is essential during early lymphocyte development. Patra and colleagues identify a distinct IL-7–kinase Jak3–dependent pathway that activates the transcription factor NFATc1 in DN1 thymocytes to promote their survival.

Amiya K Patra
Andris Avots
Edgar Serfling
Research23 Dec 2012
Nature Immunology

Volume: 14, P: 127-135
Citrin mediated metabolic rewiring in response to altered basal subcellular Ca²⁺ homeostasis

Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca²⁺ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this process and show that manipulation of Ca²⁺ dynamics can reprogram cellular and mitochondrial metabolism.

Zhanat Koshenov
Furkan E. Oflaz
Wolfgang F. Graier
ResearchOpen Access20 Jan 2022
Communications Biology

Volume: 5, P: 1-15
Diacylglycerol triggers Rim101 pathway–dependent necrosis in yeast: a model for lipotoxicity

Patrick Rockenfeller
Martin Smolnig
Frank Madeo
ResearchOpen Access23 May 2018
Cell Death & Differentiation

Volume: 25, P: 767-783
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca²⁺

Markus Waldeck-Weiermair
Roland Malli
Wolfgang F. Graier
ResearchOpen Access22 Oct 2015
Scientific Reports

Volume: 5, P: 1-10

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