Blocking lymphangiogenesis holds great therapeutic potential, however, only few inhibitors are known. Here the authors show that membrane type 1-matrix metalloproteinase suppresses lymphangiogenesis by curbing both LYVE-1-mediated proliferation of lymphatic endothelial cells and production of lymphangiogenic factors by macrophages.
- Hoi Leong Xavier Wong
- Guoxiang Jin
- Zhongjun Zhou
