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Showing 1–3 of 3 results
Advanced filters: Author: Reshmi Parameswaran Clear advanced filters

  • Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targets.

    • Reshmi Parameswaran
    • Parameswaran Ramakrishnan
    • David N. Wald
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Antigen escape represents a potential drawback of chimeric antigen receptor T cell (CAR-T) therapy targeting a single tumor-associated antigen. To reduce the risk of antigen escape, here the authors report the design and characterization of a BAFF ligand CAR-T that can recognize three different receptors (BAFF-R, BCMA and TACI), demonstrating in vitro and in vivo cytotoxicity against multiple B cell cancer models.

    • Derek P. Wong
    • Nand K. Roy
    • Reshmi Parameswaran
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17