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Showing 1–2 of 2 results
Advanced filters: Author: Revati Darp Clear advanced filters

  • Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma formation.

    • Marc A. Vittoria
    • Nathan Kingston
    • Neil J. Ganem
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Whole-genome doubling (WGD) commonly occurs in many solid tumors. Here the authors use a zebrafish model of melanoma and in vitro models to show that BRAFV600E induces WGD via inhibition of RhoA and cytokinesis failure.

    • Revati Darp
    • Marc A. Vittoria
    • Craig J. Ceol
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17